El aire limpio, los espacios naturales, las dietas saludables y los fuertes vínculos sociales se asocian con una menor inflamación en la infancia

According to a new study led by the Institute of Global Health of Barcelona (ISGlobal), center imported by the «La Caixa» Foundation, in collaboration untied Better interior air quality, proximity to Startes spaces, a healthy diet and a good social network They are associated with a minor inflammation and better regulated in infancy. The results, published in International EnvironmentThey offer Newevas Perspectives on how early environmental exhibitions mold the long -term immune function and general health.

The entone in growing plays a key role in our health throughout life. He Exhibition It refers to the set of environmental exhibitions from conception, including factors such as air pollution, nutrition, stress and social context. Although many studies have explored how individual environmental factors affect child health, few have examined their joint, special environment on the Immune system regulationThat is one Central via in the development of chronic cooling such as obesity, diabetes and respiratory disorders.

This study is based on the Human Early Life Exposome (Helix) cohort, within the framework of the Athlete Projectwhich includes an 845 boys and girls from six population birth cohorts in the United Kingdom (BIB), France (Eden), Spain (Inma), Lithuania (Kanc), Norway (Moba) and Greece (Rhea). «We investigate how a wide range of prenatal and postnatal environmental exhibitions influence the Children’s immune function And how these immune profiles are related to their cardiometabolic, respiratory/allergic and neurodevelopmental health, ”explains Léa Maitre, coordinator of the Central Exhibition of Isglobal and last author of the study.

The impact of the entone on the first years of life

The authors examined 91 different environmental exhibitions During Emarazo and Childhood. These were grouped into 13 exhibition families, including exterior exhibitions Such as air pollution and green and blue spaces; Interior exhibitionsPollutants of home and chemical agents; Lifestyle factorsLike diet, physical activity, sleep and exposure to tobacco; my Socio -economic indicators As the educational level of parents, income and social support.

“To evaluate immune health, we analyze three biological levels a starting of the Sanze stakes of each child: the composition of white blood cells, the concentrations of the plasma proteins and the methylation of the DNA in white blood cells Ines aminaINSERM researcher – Grenoble Alpes University and first author of the study.

Advanced statiny models were used for Identify immune «signatures.» —Patrones in the immune system – associated with a compound health index that combines respiratory, metabolic and cognitive results. For this, a high-dimension reduction algorithm was applied, the regularized generalized cannic analysis (RGCCA), a special environment for the integration of multi-communication data in exhibition studies. This work was carried out in collaboration with the Paris-Saclay University, CNRS and Centralsupélec.

Immune profiles associated with better health

The study identified in children Three types of immune signatures Related to better general health. Two of them were based on blood proteins and showed lower levels of inflammacy. The third pattern, based on white blood cells, indicated a more balanced and well -regulated immune system. These ‘benicious signatures’ are related to environmental exhibitions species during childhood: Better interior air quality, proximity to blue spaces (Lakes, rivers or coasts), Healthier dietary patterns AND Social capital mayor (For example, social participation and family and community support).

«Our resulting highlights the import of these environmental factors in the Immunotoxicity mitigation Related with child health, «concludes Léa Maitre.» Improving interior air quality, promoting healthy diets, preserving access to natural spaces and strengthening community support systems are viable eases that can improve infamatory, key, key, community, easegias, viable easegias, can improve infammer, key, key, community processes. Cardiometabolic, respiratory and neurodevelopmental health in childhood ”.

Reference

Amine, I., Anguita-Ruiz, A., Guillien, A., Basagaña, X., Bustamante, M., Borràs, E., Cirach, M., Redele, A., Dobaedo, C., García-Aymerich, J., Granum, B., Grazuleviciene, R., González, Jr, Julvez, J., Keun, H. H. López-Vicente M., Mceachan, R., Moncunill, G., Nieuwenhuijsen, M., … Maitre, L. (2025). Exhibition of early life and immune signatures related to childhood health. International Environment, 202(109668), 109668. https://doi.org/10.1016/j.envint.2025.109668