Suplementos e intervenciones dietéticas para la salud cardiovascular, lo que dicen los ensayos

The accumulation of studies on the possible effects of a type of intervention related to diet is such that from time to time the so-called «reviews of reviewed» are appreciated, that is, those publications that review all existing reviews. And if this work also encompasses a great diversity of interventions, it will allow us to have a kind of «super summary» that can be useful to have a general perspective of the existing evidence.

In the field of nutrition, interventions are usually dietary or related to supplements, and in this field recent research is worth highlighting «Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes An Overview and Evidence Map» (2019). The document is free access, so you can read it in full by clicking on the previous link. Its authors tried to synthesize the level of evidence that can be deduced from the trials for a good number of interventions through changes in diet or with supplements, regarding their effects on cardiovascular disease and mortality. These characteristics give relevance to the review, since on the one hand, by focusing only on trials, it is based on more reliable data; and on the other, the indicators are relevant, direct results of disease and mortality, not intermediate indicators. That is, it is analyzing whether there is «top-notch» evidence.

Well, among its conclusions I wanted to highlight and bring something concrete to this blog, a table that includes, because it seemed very simple and visual to me and that it synthesizes all the results in a single figure. Although before I dared to make some small design changes, just to try to slightly improve its interpretation.

Here it is (click to enlarge):

As you can see, the information included is truly complete: More than twenty interventions, both with supplements and changes in diet; five indicators of disease and mortality (general and cardiovascular mortality, heart attack, stroke and coronary heart disease); possible general effect (no effect, benefit or harm); and strength of existing evidence (divided into four levels). All condensed into a single figure.

At first glance, possibly the most striking thing is that most of the interventions have not produced any effects on disease or mortality (gray). And that the evidence is in almost all cases low or very low (0 or 1). Which is consistent with the idea that nutrition and health research is really complex, especially when it comes to intervention trials and indicators of disease or mortality, as is the case.

For those more interested in going deeper, in the document you can find all the references used, which are many.

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